Synaptic Plasticity and the Mechanism of Alzheimer's Disease af Selkoe Dennis J / Triller Antoine / Christen Yves (Bog)

During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas – biochemical pathology and molecular genetics – combined to yield powerful clues to the molecular underpinnings of several previously "idiopathic" brain disorders. Among the classical neurodegenerative diseases, perhaps the most rapid progress occurred in research on Alzheimer’s disease (AD). In disorders like Huntington’s disease, amyotrophic lateral sclerosis and even Parkinson’s disease, unbiased genetic screens, linkage analysis and positional cloning have identified causative genes that subsequently allowed the formulation of specific biochemical hypotheses. In sharp contrast, modern research on AD developed in the opposite order: the identification of the protein subunits of the classical brain lesions guided geneticists to disease-inducing genes, for example, APP, apolipoprotein E and tau. Thus, a biochemical hypothesis of disease - that AD is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies.Forlag: SpringerUdgivelsesår: 2008Sider: 183Sprog: Engelsk Klik på 'Se annoncen hos forhandleren' for at se varen i vores webshop Vi sender til hele landet for 45 kr. Leveringstiden er 1-3 hverdage. Du kan også gratis hente den på vores lager på Industrivej 10 i Slangerup. Er du i tvivl om varen stadig er til salg? Klik på knappen "Se annoncen hos forhandleren" for at se den i vores webshop. Kan du se den der, er den stadig til salg. Orderly er en ny måde at købe brugt på. Vi har alle vores sælgeres ting på vores centrale lager. Derfor kan du være helt sikker på at få dine ting - og du kan samle flere ting på tværs af sælgere og kun betale én gang fragt.